Coinfection of Leptomonas seymouri and Leishmania donovani in Indian leishmaniasis.
نویسندگان
چکیده
Leishmania donovani is considered the causative organism of visceral leishmaniasis (VL) and post-kala-azar dermal leishmaniasis (PKDL). Testing of 4/29 DNA samples from VL and PKDL patients as well as 2/7 field isolates showed an aberrant internal transcribed spacer 1 (ITS1) restriction fragment length polymorphism (RFLP) pattern, which upon sequencing strongly matched Leptomonas seymouri, thus confirming its presence in Indian leishmaniasis.
منابع مشابه
1 Co - infection of Leptomonas seymouri with Leishmania donovani in Indian Leishmaniasis 1 Running
Co-infection of Leptomonas seymouri with Leishmania donovani in Indian Leishmaniasis 1 Running Title: Co-infection of Leptomonas seymouri with Leishmania donovani 2 3 Susmita Ghosh, Priyanka Banerjee, Avijit Sarkar, Sudipto Ganguly, Simanti Datta* 4 and Mitali Chatterjee* 5 6 Dept. of Pharmacology and Centre for Liver Research, School of Digestive and Liver 7 Diseases, Institute of Post Graduat...
متن کاملLeptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania donovani
The co-infection cases involving dixenous Leishmania spp. (mostly of the L. donovani complex) and presumably monoxenous trypanosomatids in immunocompromised mammalian hosts including humans are well documented. The main opportunistic parasite has been identified as Leptomonas seymouri of the sub-family Leishmaniinae. The molecular mechanisms allowing a parasite of insects to withstand elevated ...
متن کاملSOLiD™ Sequencing of Genomes of Clinical Isolates of Leishmania donovani from India Confirm Leptomonas Co-Infection and Raise Some Key Questions
BACKGROUND Known as 'neglected disease' because relatively little effort has been applied to finding cures, leishmaniasis kills more than 150,000 people every year and debilitates millions more. Visceral leishmaniasis (VL), also called Kala Azar (KA) or black fever in India, claims around 20,000 lives every year. Whole genome analysis presents an excellent means to identify new targets for drug...
متن کاملLeptomonas seymouri and Crithidia fasciculata exoantigens can discriminate human cases of visceral leishmaniasis from American tegumentary leishmaniasis ones
Exoantigens (exo) from Leptomonas seymouri and Crithidia fasciculata were used in an enzyme linked immunosorbent assay (ELISA), showing 100% reactivity with sera from visceral leishmaniasis (VL) cases, and no reactivity with American tegumentary leishmaniasis (ATL) ones. Our results have indicated that these exoantigens can be applied in the discrimination of VL and ATL cases.
متن کاملLaboratory Diagnosis of Visceral Leishmaniasis
The group of diseases known as the leishmaniases are caused by obligate intracellular protozoa of the genus Leishmania (39). Natural transmission of leishmania is carried out by a certain species of sandfly of the genus Phlebotomus (Old World) or Lutzomyia (New World). These are present in three different forms: (i) visceral leishmaniasis (VL), (ii) cutaneous leishmaniasis, and (iii) mucocutane...
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ورودعنوان ژورنال:
- Journal of clinical microbiology
دوره 50 8 شماره
صفحات -
تاریخ انتشار 2012